Background: The intention of nurses for career change can have negative consequences on how health-care systems and organizations function. At a time of current nursing shortage, it is important to understand the reasons why nurses decided to leave the profession. Aim: This study aimed to explore and determine the influence of occupational satisfaction on career change decision among nurses working at different Sohag city hospitals. Subject and Methods: Descriptive exploratory design was adopted to conduct this study. The study was conducted at the Main three governmental hospitals in Sohag city. The study participants were (250) all categories of nursing staff from all age categories and different educational levels. Tools: Occupational Satisfaction questionnaire and Anticipated Career Change questionnaire were used for data collection. Results: Based on the participant`s responses, the results revealed that there is a significant negative correlation between occupational satisfaction and career change decision(r= -0.166, P=0.005). The highest percentage of participants dissatisfied about treating conflict among nurses and doctor within their organizations and agreed that the organization didn’t care about their well-being. Conclusion: The study revealed that more than half of the participants dah the career change decision for different sets of factors associated with occupational satisfaction. This knowledge is important for health care managers to understanding predictors of career change among nurses which help them to formulate strategic plans to maximize nurse’s attraction and retention in the workforce