lobna.nassr

Lobna Abdel-Mohsen Ebaid Nassr

Professor - Head Of Chemistry Department- Director of Quality Management Unit - Faculty of Science - Sohag University

Faculty of science

Address: Chemistry Department - Faculty of Science - Sohag University

53

Like
9 58 19 49 5 36 2K 1.3K
220

Newly Added
  • Courses 9
  • Course Supplements 58
  • Courses Tasks 19
  • Publications 49
  • Office hours 5
  • Announcements 36
  • File uploaded 56
  • Downloaded Times 161

Publications Which contain the keyword: Synthesis

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

2020-02-04 19:06:32 Keywords HDACs Inhibitors;, Ligustrazine, , Anticancer agents, , In silico study, , Synthesis,
Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
INTRODUCTION: Histone deacetylases (HDACs) represent one of the most validated cancer targets. The inhibition of HDACs has been proven to be a successful strategy for the development of novel anticancer candidates. METHODS: This work describes design and synthesis of a new set of HDAC inhibitors ( 7A-C and 8A, B) utilizing ligustrazine as a novel cap moiety, and achieving the ... Read more

Synthesis of maximally entangled mixed states and disentanglement in coupled Josephson charge qubits

2018-12-13 11:56:19 Keywords Synthesis, maximally entangled, Disentanglement, Josephson charge qubits,
Synthesis of maximally entangled mixed states and disentanglement in coupled Josephson charge qubits
We analyze a controllable generation of maximally entangled mixed states of a circuit containing two-coupled superconducting charge qubits. Each qubit is based on a Cooper pair box connected to a reservoir electrode through a Josephson junction. Illustrative variational calculations were performed to demonstrate the effect on the two-qubits entanglement. At sufficiently deviation between the Josephson energies of the qubits and/or ... Read more

Synthesis, Characterization and Biological Studies of Some new Cr(III), Fe(III) and Cu(II) Complexes based on Multi-Substituted Aryl Imidazole ligand

2018-11-25 17:26:51 Keywords Synthesis, DNA interaction, DFT studies, Antimicrobial activity, IR, TGA, Imidazole Ligand,
Synthesis, Characterization and Biological Studies of Some new Cr(III), Fe(III) and Cu(II) Complexes based on Multi-Substituted Aryl Imidazole ligand
New Cr (III), Fe (III) and Cu (II) complexes with MSBB (2‐(1‐butyl‐4,5 diphenyl‐1H‐imidazol‐2‐yl)(4-bromophenol) were synthesized. The multi-substituted aryl imidazole ligand (MSBB) and its complexes were characterized by using elemental and thermal analysis, molar conductivity, magnetic susceptibility, UV-Vis spectral data, IR, and NMR. The obtained data showed that prepared complexes were 1 :1 (metal : ligand) ratio, octahedral (Oh) for all ... Read more

Synthesis of a Library of 2-Alkyl-3-alkyloxy-2 H -indazole-6-carboxamides

2018-11-01 08:55:29 Keywords 2-Alkyl-3-alkyloxy-2 H -indaz, Synthesis, Chemsitry,
Synthesis of a Library of 2-Alkyl-3-alkyloxy-2 H -indazole-6-carboxamides
A library of 200 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides was synthesized using parallel solution-phase methods. The indazole cyclization reaction was optimized for library production with the best yields resulting from controlled alcohol/water solvent ratios. The key step, a heterocyclization reaction, proceeds by N,N-bond formation and delivers the 2H-indazole scaffold. Automated preparative HPLC was utilized to provide pure compounds on a 10+ mg scale. Read more

New Method for Synthesis of Multi-substituted Imidazoles

2018-10-03 08:46:32 Keywords Multi-substituted Imidazoles, Synthesis, alkylation, one-pot Multicomponent synthes,
New Method for Synthesis of Multi-substituted Imidazoles
Here, we reported two methods for the synthesis of multi-substituted imidazoles,firstly via four-component cyclocondensation reaction of benzil, aliphatic amines (allylamine or pentylamine), and aromatic aldehyde and ammonium acetate. Using an ionic liquid catalyst namely, diethyl ammonium hydrogen sul-fate, and under solvent-free conditions. Secondly, via the alkylation of synthesized NH imidazoles with alkyl halide (allyl bromide and pentyl bromide) gave8a–cin high ... Read more

Synthesis and Antimicrobial Activity of Substituted Nitrotetrazole-5-Carbaldehyde Hydrazones

2018-09-18 21:48:27 Keywords Synthesis, nitrotetrazole-5-carbaldehyde, Antimicrobial activity, minimum inhibitory concentrati,
Synthesis and Antimicrobial Activity of Substituted Nitrotetrazole-5-Carbaldehyde Hydrazones
A series of substituted -nitrotetrazole-5-carbaldehyde hydrazones were synthesized and tested for antimicrobial activity with respect to _Staphylococcus aureus_, _Streptococcus pneumoniae_, _E. coli_, _P. aeruginosa_, and _Micrococcus_. The minimum inhibitory concentrations were determined. Read more

Synthesis and Antifungal Activity of Substituted Nitrotetrazole-5-Carbaldehyde Hydrazones

2018-09-18 21:51:09 Keywords Synthesis, nitrotetrazole-5-carbaldehyde, antifungal activity,
Synthesis and Antifungal Activity of Substituted Nitrotetrazole-5-Carbaldehyde Hydrazones
A series of nitrotetrazole-5-carbaldehyde hydrazones was synthesized and their antifungal activity against _Candida albicans_, _Microsporum canis_, and _Trichophyton rubrum_ was assessed. Read more

Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of three new nano-sized Cu(II), Co(II) and Ni(II) chelates

2018-09-16 21:50:05 Keywords Antimicrobial activity, Synthesis,
Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of three new nano-sized Cu(II), Co(II) and Ni(II) chelates
Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of three new nano-sized Cu(II), Co(II) and Ni(II) chelates based on tri-dentate NOO imine ligands as precursors for metal oxides Read more

Nano structure Iron (II) and Copper (II) Schiff base complexes of a NNO-tridentate ligand as new antibiotic agents: spectral, thermal behaviors and DNA binding ability

2018-09-16 13:40:18 Keywords TGA, NMR, IR, Calf thymus DNA, Antimicrobial activity, Synthesis, characterization, Nano particle, DNA interaction,
Nano structure Iron (II) and Copper (II) Schiff base complexes of a NNO-tridentate ligand as new antibiotic agents: spectral, thermal behaviors and DNA binding ability
Complexes of Fe (II) and Cu (II) with a tridentate Schiff base, 2-((z)-(pyridine-2-ylimino) methyl) naphthalene1-ol derived from 2-hydroxy-1-napthaldehyde and 2-aminopyridine were synthesized. Both the ligand and its complexes were characterized on the basis of microanalysis, melting point, 1H and 13CNMR, molar conductivity, thermal analysis, IR and UV/Vis spectral studies. From analytical data, the stoichiometry of the complexes was found to ... Read more

Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of nano-sized Cu(II), Co(II) and Ni(II) chelates as precursors for metal oxides

2018-09-11 14:15:14 Keywords sonochemistry, Synthesis, thermal analyses, Antimicrobial activity, DNA interaction, Cytotoxic activity, nanoparticles, IR, NMR, TGA,
Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of nano-sized Cu(II), Co(II) and Ni(II) chelates as precursors for metal oxides
Three new nano sized Cu(II), Co(II) and Ni(II) complexes of imine ligand derived from the condensation of 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared and investigated using various chemical techniques such as NMR, elemental analysis, molar conductance, IR, electronic spectra, TGA and magnetic momentmeasurements. The obtained chemical analysis data showed that the synthesis of 1:1 (metal:ligand) ratio and octahedral geometry was ... Read more

  • «
  • 1
  • »